TEST OF THE EFFECTIVENESS OF DUTCH EGGPLANT FRUIT KOMBUCHA (Solanum betaceum Cav.) ON THE DECREASE IN BLOOD GLUCOSE LEVELS OF MALE MICE (Mus musculus) INDUCED GLUCOSE

Abstract

Diabetes mellitus is a disease characterized by increased blood glucose levels above normal levels. Many traditional treatments are used, one of which is consuming tamarillo (Solanum betaceum Cav.) kombucha to lower blood glucose levels. Kombucha is the result of fermentation of tea and glucose by a kombucha starter culture called SCOBY (Symbiotic Colon Of Bacteria and Yeast).  This research was conducted to determine the effect of KBTB on the blood glucose levels of mice burdened with glucose. This research is an experimental study using 25 mice and divided into five groups. Group I (comparison), group II (solvent control), CMC 0.5%, groups III, IV, V (treatment) KBTB doses of 9 ml/kgBB, 18 ml/kgBB and 36 ml/kgBB. Administration to mice orally and blood glucose levels measured. Blood glucose levels were determined at baseline, fasting, 15, 30, 45, 60, 75, 90, 105 and 120 minutes. Blood glucose levels for each group were analyzed statistically using the One Way ANOVA method and Duncan's Post-Hoc test using SPSS 25.0 . The results of statistical tests on blood glucose levels between the glibenclamide and KBTB groups showed that there was no significant difference with an α value > 0.05. From the research results, it can be concluded that KBTB has the activity of reducing blood glucose levels in mice induced by glucose with an effective dose of 18 ml/kgBW.